948291-50-7

Usage

InChI:InChI=1/C11H9Cl2N/c1-7-3-2-4-8-5-9(6-12)11(13)14-10(7)8/h2-5H,6H2,1H3

Upstream product

• 333408-31-4 2-chloro-3-(hydroxymethyl)-8-methylquinoline 
• 73568-26-0 2-chloro-8-methyl-quinoline-3-carbaldehyde 

Downstream Products

• 1269985-93-4 3-chloro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]-4-fluoroaniline 
• 606095-54-9 N-[(2-chloro-8-methylquinolin-3-yl)methyl]cyclohexylamine 
• 1269985-99-0 N-[(2-chloro-8-methylquinolin-3-yl)methyl]-4-methylaniline 
• 1269985-90-1 4-chloro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1262853-80-4 N-[(2-chloro-8-methylquinolin-3-yl)methyl]-4-methoxyaniline 
• 1269986-02-8 4-nitro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1269985-87-6 N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1269986-01-7 3-chloro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1269986-05-1 2-chloro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1269986-04-0 N-[(2-chloro-8-methylquinolin-3-yl)methyl]-3-methylaniline 
• 1269985-97-8 3,4-dichloro-N-[(2-chloro-8-methylquinolin-3-yl)methyl]aniline 
• 1269986-03-9 N-[(2-chloro-8-methylquinolin-3-yl)methyl]-2-methylaniline 
• 606095-53-8 N-benzyl-1-(2-chloro-8-methylquinolin-3-yl)methanamine 
• 1269985-91-2 N-[(2-chloro-8-methylquinolin-3-yl)-methyl]-4-fluoroaniline 

Relevant academic research and scientific papers

INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE

The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds

Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives

A new series of N-[(2-chloro-8-methylquinolin-3-yl)methyl]-(substituted)- aniline/butylamine/cyclohexylamine/benzylamine derivatives (4a-p) was synthesized by nucleophilic substitution reaction of 2-chloro-3-(chloromethyl)- 8-methylquinoline 3 with various aliphatic and aromatic amines in absolute ethanol in the presence of triethylamine (TEA). The newly synthesized secondary amines were characterized by the combined use of IR, 1H NMR, 13C NMR, mass spectral data and microanalyses. The antidepressant activity of the synthesized compounds (4a-p) was evaluated by Forced swim test in rats and their neurotoxicity was evaluated by the rotarod test. Test compounds and clomipramine were administered intraperitoneally at dose of 100 mg/kg and 20 mg/kg respectively. Preliminary antidepressant screening of compounds (4a-p) revealed that compounds 4b, 4c, 4d, 4e, 4i and 4o significantly (P 0.01) reduces the duration of immobility time. These compounds were also tested in-vitro for MAO inhibitory effect. All the compounds were also screened for antifungal activity against Aspergillus niger MTCC 281, Aspergillus flavus MTCC 277, Monascus purpureus MTCC 369 and Penicillium citrinum NCIM 768 strains.

Analysis of Cl...Cl and C-H...Cl intermolecular interactions involving chlorine in substituted 2-chloroquinoline derivatives

Six crystal structures of substituted 2-chloroquinoline derivatives have been analysed to evaluate the role of Cl atom as a self recognizing unit resulting in the formation of Cl...Cl and C-H...Cl interactions to generate supramolecular assembly in the solid state. The features of Type I and Type II geometries associated with Cl...Cl interactions have been analysed to show directional preferences leading to differences in the packing motifs in these crystal structures. C-H...Cl interactions are generated exclusively in structures depicting Type II Cl...Cl interaction have been observed in these structures. Indian Academy of Sciences.