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Usage

Uses

Used in Pharmaceutical Industry:
4-[1-[4-(AMINOSULFONYL)PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL]BENZOIC ACID is used as an intermediate in the synthesis of various pharmaceutical compounds, including Celebrex, a popular anti-inflammatory drug. Its unique structure allows it to be a key component in the development of new drugs with improved therapeutic properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-[1-[4-(AMINOSULFONYL)PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL]BENZOIC ACID serves as a versatile building block for the creation of a wide range of organic compounds. Its functional groups can be further modified or reacted with other molecules to produce new compounds with specific properties and applications.
Used in Research and Development:
4-[1-[4-(AMINOSULFONYL)PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL]BENZOIC ACID is also utilized in research and development settings, where it can be studied for its potential applications in various fields. Scientists and researchers can use 4-[1-[4-(AMINOSULFONYL)PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL]BENZOIC ACID to explore new chemical reactions, investigate its properties, and develop new methods for its synthesis and application.

Upstream product

• 219986-59-1 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide 
• 147381-60-0 3-cyano-6-(4-tolyl)-4-trifluoromethyl-2(1H)-pyridone 
• 874-60-2 4-methyl-benzoyl chloride 
• 187812-31-3 1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one 

Relevant academic research and scientific papers

Facile synthesis of α-functionalized vinyl sulfides bearing β-trifluoromethyl group: a highly potential CF3-containing building blocks

The β-(trifluoromethyl)vinylsulfides on treatment with n-BuLi/TMEDA were readily lithiated at α-position of the sulfanyl group, and the generated α-lithiovinylsulfides were trapped with a variety of electrophiles to give the corresponding β-trifluoromethy

A novel approach to the synthesis of 5-trifluoromethyl-3-substituted pyrazoles

The 3-cyano-4-trifluoromethyl-6-phenyl or substituted phenyl 2(1H) pyridones (1) on reaction with hydrazine hydrate, gave exclusively in 5-trifluoromethyl-3-substituted pyrazoles (3) through a novel method. A possible mechanistic pathway for change in the

Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides

The synthesis of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides (2a-g) from the direct cyclo-condensation reaction of β-alkoxyvinyl trifluoromethyl ketones (1a-g) with thiosemicarbazide in methanol, under mild conditions, is reported. Similarly, the 1H-1-pyrazolethiocarboxyamide derivatives (2a-g) were easily dehydrated and the thiocarboxyamide group hydrolyzed in a one-step reaction by stirring with concentrated sulfuric acid to give the 3-aryl[alkyl]-5-trifluoromethyl-1H-pyrazoles (3a-g) in good yields. Specific syntheses and physical properties of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides are reported here for the first time.