94835-12-8

Basic information

• Product Name: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-(diphenylphosphino)ethyl ester
• CAS NO: 94835-12-8
• Molecular Formula: C25H34NO4P
• Molecular Weight: 443.523
• Mol File: 94835-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-(diphenylphosphino)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-(diphenylphosphino)ethyl ester(94835-12-8)
• EPA Substance Registry System: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-(diphenylphosphino)ethyl ester(94835-12-8)

Safety Data

• Hazardous Substances Data: 94835-12-8(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 2360-04-5 2-diphenylphosphinoethanol 

Downstream Products

• 94835-32-2 Leu-ODppe 
• 94835-25-3 Boc-Ala-Leu-ODppe 
• 94835-24-2 Z-Gly-Leu-ODppe 

Relevant articles and documents

THE 2-(DIPHENYLPHOSPHINO)ETHYL GROUP (DPPE) AS A NEW CARBOXYL-PROTECTING GROUP IN PEPTIDE CHEMISTRY

The use of 2-(diphenylphosphino)ethyl group for carboxyl-protection of amino acids or peptides is described.This group is easily introduced by esterification using 2-(diphenylphosphino)ethanol in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine.These Dppe esters are stable under the standard conditions for peptide synthesis.Deprotection is carried out under mild conditions by quaternisation using methyl iodide followed by a β-elimination induced by fluoride ion or potassium carbonate.