94853-30-2Relevant academic research and scientific papers
Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis
Bull, James A.,Choi, Chulho,Croft, Rosemary A.,Ding, Yujie,Dubois, Maryne A. J.,Mousseau, James J.,Owen, Dafydd R.
supporting information, p. 2045 - 2052 (2022/02/23)
Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl,gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules for drug discovery purposes. The investigation of the properties of 3,3-diaryloxetanes, particularly of interest as a benzophenone replacement, remains largely unexplored. With recent synthetic advances in accessing this motif we studied the effects of 3,3-diaryloxetanes on the physicochemical properties of ‘drug-like’ molecules. Here, we describe our efforts in the design and synthesis of a range of drug-like compounds for matched molecular pair analysis to investigate the viability of the 3,3-diaryloxetane motif as a replacement group in drug discovery. We conclude that the properties of the diaryloxetanes and ketones are similar, and generally superior to related alkyl linkers, and that diaryloxetanes provide a potentially useful new design element.
Synthesis of Aromatic Monoterpenyl Geranyl Ethers as Possible Insect Juvenile Hormon Mimics
Phadnis, A. P.,Nanda, B.,Patwardhan, Sarita A.,Gupta, A. S.
, p. 1098 - 1102 (2007/10/02)
Substituted phenyl geranyl (IX-XV, XXIV-XXVIII) and 7-methoxygeranyl ethers (XVI-XXIII, XXVIII) have been synthesised as possible juvenile hormon (JH) mimics.Out of these ethers only XVII, XVIII and XXIII show low JH activity.
