948558-69-8

Upstream product

• 625437-38-9 cyclopropyl-(2,3-dimethyl-benzyl)-amine 
• 372-09-8 cyanoacetic acid 
• 5779-93-1 2,3-dimethylbenzaldehyde 

Downstream Products

• 948558-71-2 (E)-3-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-thiazol-5-yl}-2-cyano-N-cyclopropyl-N-(2,3-dimethyl-benzyl)-acrylamide 
• 1056555-00-0 (2E)-2-cyano-N-cyclopropyl-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-(2,3-dimethylbenzyl)acrylamide 

Relevant academic research and scientific papers

Primary Amines as Renin Inhibitors

The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.