948837-86-3

Basic information

• Product Name: C₁₂H₁₂F₂O₂S₃
• CAS NO: 948837-86-3
• Molecular Weight: 322.421
• Mol File: 948837-86-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₂F₂O₂S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₂F₂O₂S₃(948837-86-3)
• EPA Substance Registry System: C₁₂H₁₂F₂O₂S₃(948837-86-3)

Safety Data

• Hazardous Substances Data: 948837-86-3(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 141134-24-9 1-(4-difluoromethoxyphenyl)-2-bromoethan-1-one 
• 811-51-8 sodium thioethylate 

Relevant articles and documents

Trithiocarbonates-Exploration of a new head group for HDAC inhibitors

Inhibition of histone deacetylases class I/II enzymes is a new, promising approach for cancer therapy. In the present study, we disclose a new structural class of HDAC inhibitors with the trithiocarbonate motif. A clear structure-activity-relationship was obtained for the cap-linker motif and the putative Zn2+ complexing head group. Selected analogs display potent inhibition of HDAC enzymatic activity and a cellular potency comparable to that of suberoylanilide hydroxamic acid (SAHA), recently approved for treatment of patients with advanced cutaneous T-cell lymphoma.