948846-61-5

Usage

Uses

Used in Pharmaceutical Industry:
(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-b]pyrrole is used as a reactant in the synthesis of histamine H3 receptor antagonists. These antagonists are important in the development of medications for various conditions, including cognitive disorders, sleep-wake regulation, and other neurological and psychiatric disorders. (3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-b]pyrrole's unique structure and reactivity make it a valuable building block in the creation of these therapeutic agents.

Upstream product

• 370880-09-4 (3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 128740-02-3 ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 
• 128740-03-4 N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester 
• 370879-99-5 ethyl (3aR,6aR)-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydro-pyrrolo[3,2-c]pyrrole-5-carboxylate 
• 370880-03-8 (3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole 
• 1421372-15-7 (3aR,6aR)-5-methyl-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,2-c]pyrrole 
• 948846-60-4 (3aR,6aR)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 948846-62-6 (3aR,6aR)-1-(4-bromo-phenyl)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole 
• 1176846-91-5 (3aR,6aR)-1-biphenyl-4-yl-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole 
• 1176846-92-6 (3aR,6aR)-1-biphenyl-3-yl-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole 
• 948845-59-8 (3aR,6aR)-1-[4'-(5-methyl-octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-yl]-ethanone 
• 948846-75-1 (3aR,6aR)-5-methyl-1-(4-piperazin-1-yl-phenyl)-octahydro-pyrrolo[3,4-b]pyrrole 
• 948846-22-8 2-{5-[4-((3aR,6aR)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-phenyl]-pyridin-2-yl}-2H-pyridazin-3-one 
• 948846-79-5 (3aR,6aR)-5-methyl-1-(4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)-phenyl)-octahydro-pyrrolo[3,4-b]pyrrole 

Relevant academic research and scientific papers

2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER

The present invention relates to certain 2-(2,4,5-substituted-anilino) pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES

The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for making the compounds, salts, and polymorphs, and methods of treating conditions and disorders using

Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships

A new histamine H3 receptor (H3R) antagonist chemotype 1 was designed by combining key pharmacophoric elements from two different precursor structural series and then simplifying and optimizing the resulting combined structural featu

DETERMINATION OF HISTAMINE-3 BIOACTIVITY

The invention relates to an in vivo method for determining the bioactivity of chemical compounds as histamine-3 receptor (H3R) ligands, and provides animal models to determine such bioactivity. The invention further relates to methods for scree

OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES

Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making th