948853-48-3

Upstream product

• 74-83-9 methyl bromide 
• 60798-08-5 4-(3-methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)benzonitrile 
• 17672-27-4 4-hydrazinobenzonitrile 
• 35496-25-4 4-(3-methyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-benzonitrile 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Copper-catalyzed acylation of pyrazolones with aldehydes to afford 4-acylpyrazolones

Copper-catalyzed direct acylation of the alkenyl C-H bond in 1,2-dihydro-3H-pyrazol-3-ones has been developed, affording a series of 4-acylpyrazolones in moderate to good yields. Notably, this protocol involves readily accessible substrates and reagents, which have good functional group tolerance leading to pyrazolone derivatives under mild reaction conditions.

Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists

The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.