948883-92-9Relevant academic research and scientific papers
Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines
Glotz, Gabriel,Lebl, René,Dallinger, Doris,Kappe, C. Oliver
supporting information, p. 13786 - 13789 (2017/10/09)
A continuous-flow process for the in situ on-demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide that makes use of membrane-separation technology is described. In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate–bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in-line FTIR technology. With the Br2 and BrCN generators connected in series, 0.2 mmol BrCN per minute was produced, which corresponds to a 0.8 m solution of BrCN in dichloromethane. The modular Br2/BrCN generator was employed for the synthesis of a diverse set of biologically relevant five- and six-membered cyclic amidines and guanidines. The set-up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi-batch mode.
Structural studies of 1-aryl-2-aminoimidazolinium bromides: Focus on tautomer preference of the 2-aminoimidazoline moiety in the solid state
Dobrowolski,Cyranski,Pisklak,Wawer,Matosiuk
, p. 1037 - 1048 (2008/09/17)
The crystal structures of five 1-(4-X-phenyl)-2-aminoimidazolinium bromides (where X = -OCH3, -CH3, -H, -Cl and -NO2) were determined by X-ray crystallography with the aim to investigate the tautomer preference of the amin
