948890-20-8Relevant academic research and scientific papers
Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines
Kozikowski,Simoni,Manfredini,Roberti,Stoelwinder
, p. 5333 - 5336 (1996)
In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.
Positional linker effects in haptens for cocaine immunopharmacotherapy
Ino, Akira,Dickerson, Tobin J.,Janda, Kim D.
, p. 4280 - 4283 (2008/02/10)
Cocaine use remains a serious problem, despite intensive efforts to curb abuse. Given the lack of effective pharmacotherapeutics for the treatment of cocaine addiction, research groups have targeted immunopharmacotherapy in which the drug user's immune sy
