948988-98-5Relevant academic research and scientific papers
On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin
Medve, Laura,Achilli, Silvia,Serna, Sonia,Zuccotto, Fabio,Varga, Norbert,Thépaut, Michel,Civera, Monica,Vivès, Corinne,Fieschi, Franck,Reichardt, Niels,Bernardi, Anna
, p. 14448 - 14460 (2018)
A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
