Chemistry - A European Journal p. 14448 - 14460 (2018)
Update date:2022-08-05
Topics:
Medve, Laura
Achilli, Silvia
Serna, Sonia
Zuccotto, Fabio
Varga, Norbert
Thépaut, Michel
Civera, Monica
Vivès, Corinne
Fieschi, Franck
Reichardt, Niels
Bernardi, Anna
A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
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