949006-95-5Relevant articles and documents
Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
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Page/Page column 17-18, (2008/06/13)
Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.