949009-93-2Relevant academic research and scientific papers
Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs
Minutolo,Cascio,Carboni,Bisogno,Prota,Bertini,Digiacomo,Bifulco,Di Marzo,Macchia
, p. 4878 - 4881 (2008/02/13)
Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.
