94902-90-6Relevant academic research and scientific papers
Chemical synthesis of UDP-Glc-2,3-diNAcA, a key intermediate in cell surface polysaccharide biosynthesis in the human respiratory pathogens B. pertussis and P. aeruginosa
Rejzek, Martin,Kannathasan, Velupillai Sri,Wing, Corin,Preston, Andrew,Westman, Erin L.,Lam, Joseph S.,Naismith, James H.,Maskell, Duncan J.,Field, Robert A.
supporting information; experimental part, p. 1203 - 1210 (2009/05/30)
In connection with studies on lipopolysaccharide biosynthesis in respiratory pathogens we had a need to access potential biosynthetic intermediate sugar nucleotides. Herein we report the chemical synthesis of uridine 5′-diphospho 2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid (UDP-Glc-2,3-diNAcA) (1) from N-acetyl-D-glucosamine in 17 steps and ～9% overall yield. This compound has proved invaluable in the elucidation of biosynthetic pathways leading to the formation of 2,3-diacetamido-2,3-dideoxy-D- mannuronic acid-containing polysaccharides. The Royal Society of Chemistry 2009.
Tunable ligands for asymmetric catalysis: Readily available carbohydrate-derived diarylphosphinites induce high selectivity in the hydrovinylation of styrene derivatives
Park, Haengsoon,RajanBabu
, p. 734 - 735 (2007/10/03)
Only a limited number of ligands have been successfully employed for the Ni-catalyzed asymmetric hydrovinylation reaction. Diarylphosphonites prepared from readily available carbohydrates in conjunction with a highly dissociated counterion ([3,5-(CF3
