94903-76-1Relevant academic research and scientific papers
[4 + 2] Cycloadditions of rigid s-cis dienes to C60. A synchronous Diels-Alder reaction
Chronakis, Nikos,Orfanopoulos, Michael
, p. 545 - 548 (2007/10/03)
(Matrix presented) The Diels-Alder reaction of rigid s-cis dienes with C60 occurs by a concerted mechanism, via a symmetrical transition state.
Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides to Isopropyl Hemiesters with Ti-TADDOLates: An Alternative to Hydrolytic Enzymes?
Jaeschke, Georg,Seebach, Dieter
, p. 1190 - 1197 (2007/10/03)
The Lewis acid mediated transfer of an alkoxide ligand from the chiral ligand sphere of Ti - TADDOLate (1) to cyclic meso anhydrides to afford the corresponding hemiesters is described. By using this method a variety of structurally different anhydrides can be converted to isopropyl hemiesters with high enantioselectivities (enantiomer ratios up to 99:1). We have also investigated Lewis acidic titanium complexes, which differ from 1 in the chiral ligand or the alkoxide ligand that is transferred. Finally, a catalytic version, which allows the substoichiometric use of Ti- TADDOLate in the presence of stoichiometric amounts of Al(Oi-Pr)3, is presented.
Efficient in-situ redox catalytic NAD(P)+ regeneration in enzymatic synthesis using transition-metal complexes of 1,10-phenanthroline-5,6-dione and its N-monomethylated derivative as catalysts
Hilt, Gerhard,Lewall, Burhanshah,Montero, Guillermo,Utley, James H. P.,Steckhan, Eberhard
, p. 2289 - 2296 (2007/10/03)
In comparative studies, we have been able to demonstrate that redox catalysts based on transition-metal complexes using 1,10-phenanthroline-5,6-dione as a ligand or based on N-methylated 1,10-phenathroline-5,6-dione acting via hydride ion abstraction are superior to alternative methods for the redox catalytic aerobic or indirect electrochemical in situ NAD(P)+ regeneration in enzymatic syntheses using alcohol dehydrogenases as production enzymes. Under preparative conditions in the gram scale we were able to obtain turnover frequencies of up to 130 turnovers per hour with respect to the redox catalyst. These are far larger than those of the presently most popular regeneration system. Wiley-VCH Verlag GmbH, 1997.
Synthesis of Four Chiral Pharmaceutical Intermediates by Biocatalysis
Patel, Ramesh N.,Banerjee, Amit,Szarka, Laszlo J.
, p. 1247 - 1264 (2007/10/03)
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates.These include: (i) the microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic ethyl ester to (3S,5R)-dihydroxy-6-(benzyloxy) he
Enzymes in organic synthesis. 32. Stereospecific horse liver alcohol dehydrogenase-catalyzed oxidations of exo- and endo-oxabicyclic meso diols
Jones, J. Bryan,Francis, Christopher J.
, p. 2578 - 2582 (2007/10/02)
Preparative-scale horse liver alcohol dehydrogenase-catalyzed oxidation of meso exo- and endo-7-oxabicycloheptane diols provides a direct one-step route to enantiomerically pure chiral γ-lactones of the oxabicyclic series.
Synthesis of thromboxane A2 analogue (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa thromboxane A2
Kametani, Tetsuji,Suzuki, Toshio,Tomino, Akiko,Kamada, Shinko,Unno, Katsuo
, p. 905 - 908 (2007/10/02)
A synthesis of the thromboxane A2 analogue, (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa-thromboxane A2 (TXA2) starting from the exo-adduct 3 of maleic anhydride and furan is described
A SIMPLE SYNTHESIS OF BICYCLOHEPTANE SYSTEM,A KEY POTENTIAL INTERMEDIATE FOR STABLE PROSTAGLANDIN H2 ANALOGUE
Suzuki, Toshio,Tomino, Akiko,Matsuda, Yasuyuki,Unno, Katsuo,Kametani Tetsuji
, p. 1735 - 1738 (2007/10/02)
A simple and efficient synthesis of 6-cyanomethyl-1-methoxycarbonylbicycloheptane system leading to stable prostaglandin H2 analogue is described.
