949035-05-6

Upstream product

• 863881-19-0 1-[4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1228023-20-8 3-oxo-4-[1',1'-dimethyl-1'-(4-bromo-1-methylindol-3-yl)-methyl]-6-methylene-7-(tert-butyldiphenylsilyloxy)-heptanoate methyl ester 
• 1228023-15-1 O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol 
• 1228023-16-2 (Z)-methyl 8,9-dihydro-7-hydroxy-8-(2-(tert-butyldiphenylsilyloxymethyl)allyl)-2,9,9-trimethyl-2H-cyclohepta[cd]indole-6-carboxylate 
• 1392127-50-2 (E)-methyl 4-[5-(benzoyloxy)-2-oxopent-3-en-1-yl]-5-[(tert-butyldimethylsilyl)oxy]-1,3,3-trimethyl-3,4-dihydro-1H-cyclohepta[cd]indole-6-carboxylate 

Relevant academic research and scientific papers

Towards the syntheses of N-H and N-alkylated derivatives of meridianins

(Chemical Equation Presented) Novel N-H and N-alkylated derivatives of meridianins have been synthesized as potential antitumor agents by a two-step conversion of N-tosyl-3-acetylindoles or N-alkyl-3-acetylindoles to the corresponding enaminones using DMF-DMA, with or without added pyrrolidine. Further cyclization with guanidine gave the corresponding 2-aminopyrimidines. The structures of the compounds, thus obtained, were proved by 1H and 13C NMR spectroscopy, NOE experiments and X-ray analysis.