1228023-16-2

Upstream product

• 1228023-20-8 3-oxo-4-[1',1'-dimethyl-1'-(4-bromo-1-methylindol-3-yl)-methyl]-6-methylene-7-(tert-butyldiphenylsilyloxy)-heptanoate methyl ester 
• 1228023-15-1 O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol 
• 949035-05-6 4-bromo-3-acetyl-1-methyl-1H-indole 
• 590417-55-3 4-bromo-1-methyl-1H-indole 
• 52488-36-5 4-bromo-1H-indole 
• 1228023-14-0 6-(4-tert-butyldiphenylsilyloxy-3-methylidenebutyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 1228023-13-9 tert-butyl 7-tert-butyldiphenylsilanyloxy-6-methylidene-hept-3-one-ate 
• 913253-34-6 {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane 
• 177606-51-8 2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol 
• 1441119-24-9 C₁₂H₁₄BrNO 
• 1228023-12-8 C₃₀H₄₂O₄Si₂ 

Relevant academic research and scientific papers

Studies toward welwitindolinones: Formal syntheses of N- methylwelwitindolinone C isothiocyanate and related natural products

The formal syntheses of N-methylwelwitindolinone C isothiocyanate (4) and several other welwitindolinones 5-8 were achieved by the independent synthesis of 79. The synthesis featured a Lewis acid-mediated coupling between a heteroaryl carbinol and bis-TMS enol ether, an intramolecular enolate arylation, and an unprecedented intramolecular allylic alkylation of a γ-acyloxyenone.

Approaches to N-methylwelwitindolinone C isothiocyanate: Facile synthesis of the tetracyclic core

The synthesis of a functionalized, tetracyclic core of N- methylwelwitindolinone C isothiocyanate is reported. The approach features a convergent coupling between an indole iminium ion and a highly functionalized vinylogous silyl ketene acetal followed by