949096-30-4

Usage

Uses

Used in Pharmaceutical Industry:
(1S)-1-(4-FLUOROPHENYL)BUT-3-EN-1-AMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to target the central nervous system. Its unique structure allows for the development of drugs that can interact with specific receptors or enzymes, potentially leading to treatments for neurological disorders or mental health conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (1S)-1-(4-FLUOROPHENYL)BUT-3-EN-1-AMINE serves as a valuable compound for studying the structure-activity relationships of psychoactive substances and other bioactive compounds. Understanding how its molecular structure influences biological activity can inform the design of more effective and safer medications.
Used in Drug Development:
(1S)-1-(4-FLUOROPHENYL)BUT-3-EN-1-AMINE is utilized in drug development as a starting material or a building block for creating new molecules with potential therapeutic effects. Its chiral nature and unique substitution pattern make it a promising candidate for the creation of enantiomerically pure drugs, which can exhibit improved efficacy and reduced side effects compared to their racemic counterparts.

Upstream product

• 39769-08-9 N-(4-fluorobenzylidene)-4-methoxyaniline 
• 459-57-4 4-fluorobenzaldehyde 
• 115504-61-5 N'-[(4-fluorophenyl)methylidene]benzeneacylhydrazone 
• 1242159-24-5 (S)-N'-[1-(4-fluorophenyl)but-3-enyl]benzohydrazide 
• 949020-95-5 methyl N-[1(S)-(4-fluorophenyl)-3-buten-1-yl]-(S)-valinate 
• 85116-38-7 (+)-diisopinocampheylallylborane 
• 949021-02-7 N-[1(S)-(4-fluorophenyl)-3-buten-1-yl]-(S)-valinol 
• 108-21-4 Isopropyl acetate 
• 1159883-05-2 1-(4-fluorophenyl)-but-3-en-1-amine 

Downstream Products

• 949021-21-0 (S)-N-[1-(4-fluorophenyl)-3-buten-1-yl]propenamide 
• 1392047-81-2 (2S)-2-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine 

Relevant academic research and scientific papers

Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols

Chiral biphenols catalyze the asymmetric Petasis borono-Mannich allylation of aldehydes and amines through the use of a bench-stable allyldioxaborolane. The reaction proceeds via a two-step, one-pot process and requires 2–8 mole % of 3,3′-Ph2-BINOL as the optimal catalyst. Under microwave heating the reaction affords chiral homoallylic amines in excellent yields (up to 99 %) and high enantioselectivies (er up to 99:1). The catalytic reaction is a true multicomponent condensation reaction whereas both the aldehyde and the amine can possess a wide range of structural and electronic properties. Use of crotyldioxaborolane in the reaction results in stereodivergent products with anti- and syn-diastereomers both in good diastereoselectivities and enantioselectivities from the corresponding E- and Z-borolane stereoisomers.

Asymmetric synthesis of highly enantioenriched 2-substituted piperidines and 6-substituted piperidine-2-ones by a combination enantioselective hydrazone allylation with ring closing metathesis

An efficient method for the asymmetric synthesis of highly optically pure 2-substituted piperidines and 6-substituted piperidine-2-ones from aldehydes was developed by a sequence of enantioselective hydrazone allylation and ring closing metathesis. This m

Synthesis of enantiopure benzyl homoallylamines by indium-mediated barbier-type allylation combined with enzymatic kinetic resolution: Towards the chemoenzymatic synthesis of N-containing heterocycles

Barbier-type indium-mediated allylations of different N, N(dimethylsulfamoyl)-protected aldimines with a number of allyl bromides followed by high-yielding deprotection afforded allylic amines in good to excellent yields, The racemic amines were then subj

γ-Fluorophenyl-GABA derivatives from fluorobenzonitriles in high diastereomeric and enantiomeric excess

An enantioselective synthesis of α-fluoroaryl homoallylic amines in 52-71% yields and 76-93% enantioselectivities has been achieved via the allylboration of the corresponding fluorinated N-aluminobenzaldimines with B-allyldiisopinocampheylborane in the pr

Asymmetric synthesis of δ-substituted α,β-unsaturated δ-lactams by ring closing metathesis of enantiomerically pure N-acryloyl-homoallylic amines

(Chemical Equation Presented) Optically pure secondary homoallylic amines, obtained by highly diastereoselective addition of allylmetal reagents to imines derived from chiral amines, were N-dealkylated, and the primary amines were converted to N-acryloyl

Convenient synthesis of stable aldimine - Borane complexes, chiral δ-amino alcohols, and γ-substituted GABA analogues from nitriles

A one-pot synthesis of stable aldimine-trialkylborane adducts, the first synthesis of C- and N-deuterated imine-borane complexes, and their application for a highly enantioselective (84-99% ee) synthesis of δ-amino alcohols and γ-substituted γ-aminobutyri