949116-79-4

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 153141-26-5 (-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one 

Downstream Products

• 949116-80-7 (3R)-3-(4-chlorophenyl)heptan-1-ol 
• 1173107-92-0 (-)-(3R)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)heptan-1-one 
• 1173107-93-1 (+)-(3S)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)heptan-1-one 
• 1173107-85-1 (-)-(3R)-3-(4-chlorophenyl)-1-(4-methylphenyl)heptan-1-one 
• 1173107-86-2 (+)-(3S)-3-(4-chlorophenyl)-1-(4-methylphenyl)heptan-1-one 
• 1610701-01-3 C₁₃H₁₇ClO₂ 
• 1462941-11-2 (R)-2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 3-(4-chlorophenyl)heptanoate 

Relevant academic research and scientific papers

Regio- and diastereoselective conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds derived from Oppolzer's sultam

Asymmetric conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds (1) has been achieved with great regioselectivity (>20:1) and good to excellent diastereoselectivity (de up to 98%). The nucleophilicity and stereospecific blockade of the Grignard reagents play a key role in controlling the regioselectivities and diastereoselectivities of the conjugate addition reaction.