949116-80-7Relevant academic research and scientific papers
Regio- and diastereoselective conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds derived from Oppolzer's sultam
Cao, Xiufang,Liu, Fang,Lu, Wenchang,Chen, Gang,Yu, Guang-Ao,Liu, Sheng Hua
, p. 5629 - 5636 (2008/09/21)
Asymmetric conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds (1) has been achieved with great regioselectivity (>20:1) and good to excellent diastereoselectivity (de up to 98%). The nucleophilicity and stereospecific blockade of the Grignard reagents play a key role in controlling the regioselectivities and diastereoselectivities of the conjugate addition reaction.
Chiral γ-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities
Cao, Xiufang,Li, Fei,Hu, Ming,Lu, Wenchang,Yu, Guang-Ao,Sheng, Hua Liu
experimental part, p. 11367 - 11375 (2010/03/31)
A novel series of chiral γ-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee va
