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Upstream product

• 147624-55-3 4-(1-(N-(2,2-diethoxyethyl)amino)-2-(benzyloxy)ethyl)-1,2-dimethoxybenzene 
• 1448706-86-2 N-(2,2-diethoxyethyl)-2-(3,4-dimethoxyphenyl)glycinol 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 1448706-79-3 N-benzyl-N-(2,2-diethoxyethyl)-2-(3,4-dimethoxyphenyl)glycinol 

Relevant academic research and scientific papers

Synthesis of calycotomine and N-methylcalycotomine using a petasis reaction-pomeranz-fritsch-bobbitt cyclization sequence

The use of aminoacetaldehyde acetals as the amine components in the one-step, three-component Petasis reaction followed by the Pomeranz-Fritsch- Bobbitt cyclization has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline alkaloids. Using this method two alkaloids, calycotomine and N-methylcalycotomine hydrochlorides, have been prepared in 61% overall yield.