949145-98-6

Upstream product

• 949145-95-3 C₂₁H₃₇NO₃Si 
• 24424-99-5 di-tert-butyl dicarbonate 
• 240798-91-8 2-(2-methylaminophenyl)propan-1-ol 
• 57591-47-6 3-(2-aminophenyl)-1-propanol 
• 125812-44-4 2-(2-(hydroxymethyl)ethynyl)aniline 
• 615-43-0 2-iodophenylamine 
• 949145-93-1 C₂₀H₃₅NO₃Si 
• 518285-15-9 1-tert-butoxycarbonylamino-2-(3-hydroxypropyl)benzene 

Downstream Products

• 949146-01-4 N-[2-(3-iodopropyl)phenyl]-N-methylcarbamic acid tert-butyl ester 
• 949145-80-6 C₁₉H₁₉NO₂ 
• 949145-74-8 C₁₅H₂₁N 
• 949145-72-6 C₁₈H₁₉N 
• 952595-72-1 C₂₄H₂₇NO₄ 
• 952595-66-3 C₂₀H₂₉NO₂ 
• 952595-55-0 C₂₃H₂₇NO₂ 

Relevant academic research and scientific papers

Asymmetric synthesis of cyclic α-amino acid derivatives by the intramolecular reaction of magnesium carbenoid with an N-magnesio arylamine

The synthesis of pipecolic acid and homopipecolic acid derivatives was developed from ω-(2-aminophenyl)-1-chloroalkyl p-tolyl sulfoxides by treatment with i-PrMgCl. An intramolecular nucleophilic substitution reaction of a magnesium carbenoid with an N-magnesio arylamine is the key step of this reaction. Proline and pipecolic acid derivatives were also synthesized from ω-(arylamino)-1-chloroalkyl p-tolyl sulfoxides by the same chemistry. Starting from enantiomerically pure (1S,RS)-1-chloro-3-[2-(N-methylamino)phenyl]propyl p-tolyl sulfoxide, enantiomerically pure (R)-pipecolic acid derivative was obtained. The intramolecular nucleophilic substitution reaction of the magnesium carbenoid with N-magnesio arylamine was proven to take place with inversion of the carbenoid carbon. The stereochemistry of these reactions is also discussed.

A route to 2-substituted tetrahydroquinolines via palladium-catalyzed intramolecular hydroamination of anilino-alkynes

(Chemical Equation Presented) The cyclization of amino-alkynes 1 in which an amino group is attached to the aromatic ring, proceeded smoothly using a catalytic amount of Pd(PPh3)4 and benzoic acid in toluene at 120°C, leading to the

A new synthesis of cyclic α-amino acid derivatives by the intramolecular reaction of magnesium carbenoid with N-magnesio arylamine as the key reaction

A new synthesis of pipecolic acid and homopipecolic acid derivative was accomplished from 1-chloroalkyl p-tolyl sulfoxides having a 2-aminophenyl group at the ω-position by treatment with i-PrMgCl via the intramolecular reaction of magnesium carbenoid wit