949155-92-4

Upstream product

• 1376678-62-4 C₂₄H₂₈O₂S₄ 
• 626-19-7 Isophthalaldehyde 
• 41047-90-9 1,3-Bis(1,3-dithian-2-yl)benzol 
• 949155-91-3 methyl 2-(2-(3-(1,3-dioxolan-2-yl)benzoyl)-3-methoxy-3-oxopropyl)benzoate 

Downstream Products

• 149968-11-6 methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate 
• 949155-93-5 methyl 2-(3-(3-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl)-3-oxopropyl)benzoate 

Relevant academic research and scientific papers

Practical synthesis of methyl (E)-2-(3-(3-(2-(7-chloro-2-quinolinyl) ethenyl)phenyl)-3-oxopropyl)benzoate, a key intermediate of Montelukast

A novel and practical synthetic route is presented for the preparation of methyl-(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl) benzoate, the key intermediate of Montelukast, a leukotriene antagonist. The main diarylpropane framework was prepared via a polarity conversation reaction resulting in an acyl anion equivalent followed by a nucleophilic substitution reaction. The overall yield of this approach was 61%. This method is simple for operation and suitable for industrial production.

PROCESS FOR PREPARING A LEUKOTRIENE ANTAGONIST

Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation.