949159-95-9

Usage

Uses

Participate in the preparation of 4-fluoro-2-nitrobenzonitrile(an intermediate).

Upstream product

• 369-33-5 3',4'-difluoroacetophenone 
• 2002-82-6 1-(3-amino-4-fluorophenyl)ethanone 
• 64287-19-0 1-(4-fluoro-3-methoxy-phenyl)ethanone 
• 937079-77-1 1-(3-(pyridin-2-yloxy)phenyl)ethanone 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 64287-19-0 1-(4-fluoro-3-methoxy-phenyl)ethanone 
• 1072710-27-0 4'-fluoro-3'-hydroxyacetophenone-O-[(benzo[c][1,2,5]oxadiazol-5-yl)methyl]oxime 

Relevant academic research and scientific papers

Photohydration of benzophenone in aqueous acid

Why is the triplet state of aromatic ketones quenched by protons? The long-known but unexplained quenching process was investigated in detail for benzophenone (1). Adiabatic protonation of triplet benzophenone, 31, encounters a state symmetry-i

Synthesis of 2 - fluoro phenol compounds

The present invention provides a method for synthetizing a 2-fluoro phenol compound shown in a formula IV. The phenol compound shown in the formula I is prepared into a 2-pyridine oxygroup arene compound shown in a formula II through an Ullmann reaction, the 2-pyridine oxygroup arene compound shown in the formula II is mixed with a palladium catalyst, a fluorinating reagent, an additive and an organic solvent, the mixture is stirred under the temperature of 30-160 DEG C to perform a fluorination reaction to obtain an ortho-position fluoridated 2-pyridine oxygroup arene compound shown in a formula III, and the ortho-position fluoridated 2-pyridine oxygroup arene compound shown in the formula III is prepared into the 2-fluoro phenol compound shown in the formula IV through the action of alkali. The method provided by the present invention has the advantages of mild reaction conditions, simplicity in operations, good substrate adaptability, high fluorination selectivity and the like. The 2-fluoro phenol compound is shown in the figure below.

ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS

The present invention relates to arylamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

NON-STEROIDAL COMPOUNDS

The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).

PHOSPHODIESTERASE 10 INHIBITORS

The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.