949159-97-1

Basic information

• Product Name: Ethanone,1-(2-amino-4-fluoro-5-methoxyphenyl)-
• Synonyms: Ethanone,1-(2-amino-4-fluoro-5-methoxyphenyl)-;2-AMino-4-fluoro-5-Methoxyacetophenone;1-(2-Amino-4-fluoro-5-methoxyphenyl)ethanone
• CAS NO: 949159-97-1
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.18
• Mol File: 949159-97-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 312.319 °C at 760 mmHg
• Flash Point: 142.685 °C
• Appearance: /
• Density: 1.209 g/cm³
• CAS DataBase Reference: Ethanone,1-(2-amino-4-fluoro-5-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-amino-4-fluoro-5-methoxyphenyl)-(949159-97-1)
• EPA Substance Registry System: Ethanone,1-(2-amino-4-fluoro-5-methoxyphenyl)-(949159-97-1)

Safety Data

• Hazardous Substances Data: 949159-97-1(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-4-fluoro-5-methoxyphenyl)- is a chemical compound with the molecular formula C9H10FNO2. It is a synthetic organic compound that belongs to the class of ketones. This chemical is commonly used in pharmaceutical research and development, particularly in the study of potential drug candidates for the treatment of various diseases and conditions. It may also have potential applications in the field of medicinal chemistry and drug discovery. As a ketone derivative, it may exhibit certain chemical and biological properties that make it suitable for further investigation and potential use in the development of new drugs and treatments.

Upstream product

• 1262882-70-1 4-fluoro-N,3-dimethoxy-N-methylbenzamide 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 949159-96-0 1-(4-fluoro-5-methoxy-2-nitrophenyl)ethanone 
• 64287-19-0 1-(4-fluoro-3-methoxy-phenyl)ethanone 

Downstream Products

• 1378294-19-9 7-(benzyloxy)-4-bromo-6-methoxycinnoline 
• 1378294-21-3 7-(benzyloxy)-4-(6-fluoro-5-methylpyridin-3-yl)-6-methoxycinnoline 

Relevant articles and documents

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.

Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer

A radiolabeled tracer for imaging therapeutic targets in the brain is a valuable tool for lead optimization in CNS drug discovery and for dose selection in clinical development. We report the rapid identification of a novel phosphodiesterase 10A (PDE10A) tracer candidate using a LC-MS/MS technology. This structurally distinct PDE10A tracer, AMG-7980 (5), has been shown to have good uptake in the striatum (1.2% ID/g tissue), high specificity (striatum/thalamus ratio of 10), and saturable binding in vivo. The PDE10A affinity (KD) and PDE10A target density (Bmax) were determined to be 0.94 nM and 2.3 pmol/mg protein, respectively, using [ 3H]5 on rat striatum homogenate. Autoradiography on rat brain sections indicated that the tracer signal was consistent with known PDE10A expression pattern. The specific binding of [3H]5 to rat brain was blocked by another structurally distinct, published PDE10A inhibitor, MP-10. Lastly, our tracer was used to measure in vivo PDE10A target occupancy of a PDE10A inhibitor in rats using LC-MS/MS technology.