82846-18-2

Usage

Chemical Properties

White to light yellow crystal powder

InChI:InChI=1/C8H7FO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4H,1H3,(H,10,11)

Upstream product

• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 452-84-6 3-amino-4-fluorotoluene 
• 51446-31-2 4-fluoro-3-hydroxybenzoic acid 
• 74385-37-8 methyl 4-fluoro-3-methoxy-benzoate 
• 63762-79-8 2-fluoro-5-methylphenol 

Downstream Products

• 1007455-21-1 2-bromo-4-fluoro-5-methoxy-benzoic acid 
• 774232-94-9 (tert-butoxy)-N-(4-fluoro-3-methoxyphenyl)carboxamide 
• 1259307-94-2 tert-butyl 9-(4-fluoro-3-methoxybenzoyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate 
• 1260071-70-2 6,6'-bis(3-methoxy-4-fluorobenzoyl)-2,2',3,3',4,4'-(hexabenzyloxy)-α,α'-D-trehalose 
• 1260071-79-1 6,6′-bis(3-methoxy-4-fluorobenzoyl)-α,α'-D-trehalose 
• 1363148-15-5 methyl 4-(4-bromo-1H-imidazol-1-yl)-3-methoxybenzoate 
• 1363148-20-2 4-(4-bromo-1H-imidazol-1-yl)-3-methoxybenzoic acid 
• 1363148-25-7 methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzoate 
• 1363148-30-4 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzohydrazide 
• 1259307-57-7 3-(4-fluoro-3-methoxybenzoyl)-9-methyl-3,9-diazaspiro[5.5]undecane trifluoroacetate 
• 128495-47-6 2-(4-fluoro-3-methoxyphenyl)nitroethylene 
• 128495-68-1 N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-66-9 N-ethyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-67-0 N,N-di-n-propyl-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

NOVEL COMPOUNDS

The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

Pyrimido compounds having antiproliferative activity

Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.

Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives

The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as