949166-57-8Relevant academic research and scientific papers
Synthesis of benzyl diisopropyl 5-phosphonopentanoate and 5-phosphonopentanoic acid: An analog of succinyl phosphate
Weyna, David R.,Loveless, David,Bottone, Cory,Hifko, Nathan,Halkides, Christopher J.
, p. 563 - 567 (2007)
Benzyl 5-(diisopropoxyphosphoryl)pentanoate (benzyl diisopropyl 5-phosphonopentanoate) was synthesized from 5-bromopentanoic acid in three steps. The first step esterified 5-bromopentanoic acid with benzyl alcohol, the second step was a Finkelstein halogen exchange with sodium iodide, and the third step was a Michaelis-Arbuzov reaction. This compound was characterized by NMR and high-resolution mass spectrometry. This compound was hydrolyzed to produce 5-phosphonopentanoic acid, which is an analog of succinyl phosphate and a possible enzyme inhibitor. Copyright Taylor & Francis Group, LLC.
