94929-80-3

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 1384247-72-6 N-methyl-2-(acetamido)-3-(4-cyanophenyl)-2-(methylamino)propanamide 
• 1384247-64-6 N-benzyl-2-(acetamido)-3-(4-cyanophenyl)acrylamide 
• 1384247-40-8 4-(4-methoxybenzylidene)-1-benzyl-2-methylimidazol-5-one 
• 172267-41-3 2-acetylamino-(Z)- 
• 146664-09-7 N-acetyl-D- 
• 152781-30-1 D-(p-cyanophenylalanine) piperidide 
• 172267-45-7 N-acetyl-D-(p-cyanophenylalanine) piperidide 
• 167969-09-7 N-[(benzyloxy)carbonyl]-4-cyano-D-phenylalanine 
• 168039-92-7 N-benzyloxycarbonyl-D-(p-cyanophenylalanine) piperidide 
• 167969-10-0 (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide 
• 172267-46-8 N--4-cyano-D-phenylalanine piperidide 
• 172267-47-9 N--4-amidoximo-D-phenylalanine piperidide 
• 263396-44-7 (2R)-2-amino-3-(4-cyanophenyl)propanoic acid 
• 1273258-53-9 1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-4-cyanocinnamamido]-2,5-dideoxy-L-iditol 

Relevant academic research and scientific papers

Oxazolone-based photoswitches: Synthesis and properties

The synthesis, photophysics and photochemistry of a family of molecular switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophysical properties may b

Silver-Promoted Direct Phosphorylation of Bulky C(sp2)-H Bond to Build Fully Substituted β-Phosphonodehydroamino Acids

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Benzylidene-oxazolones as photoswitches: Photochemistry and theoretical calculations

The photophysics and photochemistry of a family of compounds proposed as efficient molecular photoswitches is presented. The effect of different light sources, substituents and solvents in the photostationary state has been explored. A detailed mechanisti

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.

Pseudo-peptides derived from isomannide: Inhibitors of serine proteases

In this paper, we describe the synthesis of a novel class of pseudo-peptides derived from isomannide and several oxazolones as potential inhibitors of serine proteases as well as preliminary pharmacological assays for hepatitis C. Hepatitis C, dengue and West Nile fever are among the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes and are a primary target in the drug development field. Several pseudo-peptides were obtained in good yields from the reaction of isomannide and oxazolones, and their anti-HCV potential using the HCV replicon-based assay was shown.

Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides of the formula I, in which the anions X are physiologically acceptable anions, and their analogs, which are effective inhi

Efficient Kg-Scale Synthesis of Thrombin Inhibitor CRC 220

Potent thrombin inhibitor 2 is prepared in 10 steps with 20percent overall yield from commercial 4 on a kg-scale by the convergent approach depicted in Schemes 1 and 2.The (R)-configuration of the 4-amidinophenylalanine piperidide moiety is controlled by asymmetric hydrogenation.A novel method, the hydrogenolysis of amidoximes 11 and 21, is employed to attain a particularly clean transformation of the cyano into the amidinium functionality.Despite of the amorphous nature of target compound 2, the approach is devoid of any chromatographic purification.