94930-27-5

Upstream product

• 18144-47-3 tert-butyl 4-aminobenzoate 
• 58656-98-7 tert-butyl 4-fluorobenzoate 
• 94930-28-6 N-<4'-(tert-butoxycarbonyl)phenyl>-3-pyrrolidinol 

Downstream Products

• 117098-12-1 6-<4'-(tert-butoxycarbonyl)phenyl>-2-amino-3-cyano-3a,4,5,6a-tetrahydrothieno<2,3-b>pyrrole 
• 161181-79-9 1-<4-(tert-butyloxycarbonyl)phenyl>-3-pyrrolidine 
• 161181-93-7 1-<4-(tert-butyloxycarbonyl)phenyl>-3-pyrrole 
• 953435-37-5 tert-butyl 4-(3-morpholinopyrrolidin-1-yl)benzoate 
• 117098-16-5 7-<4'-(tert-butoxycarbonyl)phenyl>-4-amino-4b,5,6,7a-tetrahydropyrrolo<3',2':4,5>thieno<2,3-d>pyrimidine 
• 94930-38-8 tert-butyl 2-acetyl-7,10-methano-5-deazapteroate 
• 94930-32-2 4-[4'-(2,2-Dicyano-vinyl)-2,3,4,5,2',5'-hexahydro-[1,3']bipyrrolyl-1'-yl]-benzoic acid tert-butyl ester 
• 94930-39-9 2-acetyl-7,10-methano-5-deazapteroic acid 
• 94930-37-7 tert-butyl 7,10-methano-5-deazapteroate 
• 94930-26-4 7,10-methano-5-deazapteroic acid 
• 94930-34-4 2-amino-3-cyano-6-<4-(tert-butoxycarbonyl)phenyl>-5,7-dihydro-6H-pyrrolo<3,4-b>pyridine 
• 154535-18-9 6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine 
• 1026005-43-5 3-(2,4-diamino-6(5H)-oxopyrimidin-5-yl)-1-<(4-tert-butyloxycarbonyl)phenyl>pyrrolidine 
• 161181-98-2 3-(2,4,6-triaminopyrimidin-5-yl)-1-(4-tert-butyloxycarbonylphenyl)pyrrolidine 

Relevant academic research and scientific papers

BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.

5-Deaza-7-desmethylene analogues of 5,10-methylene-5,6,7,8-tetrahydrofolic acid and related compounds: Synthesis and in vitro biological activity

1-[4-(tert-Butyloxycarbonyl)phenyl]-3-pyrrolidinone and 1-[3-[tert-butyloxycarbonyl)phenyl]-4-piperidinone were condensed with ethyl cyanoacetate or malononitrile to form ylidene derivatives, which were then subjected sequentially to (i) catalytic or chem

Synthesis of 4-[(1,3-diaminopyrrolo[3',4':4,5]pyrido[2,3-d]pyrimidin-8- yl)benzoyl]-L-glutamic acid as a potential antifolate

The synthesis of 4-[(1,3-diaminopyrrolo[3',4':4,5]pyrido[2,3-d]pyrimidin- 8-yl)benzoyl]-L-glutamic acid (18), a potential antifolate and anticancer agent, has been achieved starting from 1,4-dibromobutan-2-ol with alkyl p- aminobenzoic acids. Condensation of these two agents gave 1-(4- alkoxycarbonylphenyl)pyrrolidin-3-ols 7a,b, which were oxidized to the corresponding pyrrolidin-3-one derivatives 8a,b. Compounds 8a,b were converted into 1,3-diamino-8-(4-alkoxycarbonylphenyl)-7,8-dihydro-9H- pyrrolo[3',4':4,5]pyrido[2,3-d]pyrimidines 12a,b in 4 steps. Saponification of 12b the benzoate ester and coupling with di-tert-butyl glutamate afforded a mixture of 7,8-dihydro product 16 and its aromatized derivative 17. Finally hydrolysis of esters 16 or 17 gave only the title compound 18. The 7,8- dihydro tricyclic derivatives were easily air-oxidized to form their fully aromatized compounds. The title compound 18 was one tenth less active than MTX against HL-60 cells in culture.