94930-46-8

Basic information

• Product Name: 3-hydroxy-7-fluoro-1(3H)-isobenzofuranone
• Synonyms: 3-hydroxy-7-fluoro-1(3H)-isobenzofuranone
• CAS NO: 94930-46-8
• Molecular Weight: 168.124
• Mol File: 94930-46-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-7-fluoro-1(3H)-isobenzofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-7-fluoro-1(3H)-isobenzofuranone(94930-46-8)
• EPA Substance Registry System: 3-hydroxy-7-fluoro-1(3H)-isobenzofuranone(94930-46-8)

Safety Data

• Hazardous Substances Data: 94930-46-8(Hazardous Substances Data)

Upstream product

• 717816-83-6 2-dimethoxymethyl-6-fluorobenzoic acid 
• 107977-64-0 2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-6-methoxy-benzoic acid 
• 73453-77-7 3-(4,4-dimethyloxazolin 2-yl)anisole 
• 456-48-4 3-Fluorobenzaldehyde 
• 2211-82-7 7-fluoroisobenzofuran-1(3H)-one 
• 445-29-4 o-fluoro-benzoic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 10345-76-3 N,N-diethyl 2-fluorobenzamide 
• 113232-65-8 N,N-Diethyl-2-fluoro-6-formyl-benzamide 
• 107977-85-5 2-Fluoro-6-(3,4,4-trimethyl-oxazolidin-2-yl)-benzoic acid methyl ester 
• 124-38-9 carbon dioxide 
• 32347-92-5 α,α-dimethoxy-m-fluorotoluene 
• 776255-12-0 2-(3-Methoxy-2-methoxycarbonyl-phenyl)-3,4,4-trimethyl-4,5-dihydro-oxazol-3-ium 
• 586-38-9 3-Methoxybenzoic acid 

Downstream Products

• 1198117-21-3 4-fluoro-3-oxo-2-(2-(pyridin-2-yl)ethyl)-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide 
• 94930-55-9 2-(Cyano-hydroxy-methyl)-6-fluoro-benzoic acid 

Relevant articles and documents

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-π interactions and not the previously considered cation/π-π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

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