949495-46-9

Upstream product

• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 557-21-1 zinc(II) cyanide 
• 169883-33-4 2-(4-amino-3-bromophenyl)ethan-1-ol 

Downstream Products

• 949495-47-0 2-amino-5-[2-(tert-butyldimethylsilyloxy)ethyl]benzonitrile 
• 949495-63-0 ethyl ({2-cyano-4-[2-({5-hydroxy-2-[(4-methoxybenzylamino)carbonyl]-4-oxo-4H-chromen-7-yl}oxy)ethyl]phenyl}amino)(oxo)acetate 
• 949495-57-2 ethyl 7-[2-(3-cyano-4-{[ethoxy(oxo)acetyl]amino}phenyl)ethoxy]-5-hydroxy-4-oxo-4H-chromene-2-carboxylate 
• 949495-51-6 ethyl {[2-cyano-4-(2-hydroxyethyl)phenyl]amino}(oxo)acetate 
• 949495-49-2 ethyl ({4-[2-(tert-butyldimethylsilyloxy)ethyl]-2-cyanophenyl}amino)(oxo)acetate 

Relevant academic research and scientific papers

SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4

The present invention relates to novel quinazolinone derivatives of formula (I) as well as pharmaceutical compositions containing these compounds. The compounds of formula (I) as provided herein can act as positive allosteric modulators of metabotropic glutamate receptor subtype 4 (mGluR4), and can thus be used as therapeutic agents, particularly in the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions or conditions which can be affected by alteration of glutamate level or signalling.

Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors

Plasmodium falciparum lactate dehydrogenase (pfLDH) is a key enzyme for energy generation of malarial parasites and is a potential antimalarial chemotherapeutic target. It is known that the oxamate moiety, a pyruvate analog, alone shows higher inhibition