949495-63-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors
Choi, Seoung-Ryoung,Pradhan, Anupam,Hammond, Nicholas L.,Chittiboyina, Amar G.,Tekwani, Babu L.,Avery, Mitchell A.
, p. 3841 - 3850 (2008/02/11)
Plasmodium falciparum lactate dehydrogenase (pfLDH) is a key enzyme for energy generation of malarial parasites and is a potential antimalarial chemotherapeutic target. It is known that the oxamate moiety, a pyruvate analog, alone shows higher inhibition
