949536-20-3Relevant articles and documents
Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF1 receptor antagonists
Gentile, Gabriella,Di Fabio, Romano,Pavone, Francesca,Sabbatini, Fabio Maria,St-Denis, Yves,Zampori, Maria Grazia,Vitulli, Giovanni,Worby, Angela
, p. 5218 - 5221 (2008/02/12)
Corticotropin-releasing factor (CRF), a 41 amino acid peptide neurohormone synthesised by specific hypothalamic nuclei in the brain, is implicated in stress-related function. Antagonism of CRF1 receptors is an attractive therapeutic approach fo