94955-39-2Relevant academic research and scientific papers
Triazine derivatives, and pharmaceutical compositions comprising the same
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, (2008/06/13)
New triazine derivatives represented by the formula: STR1 wherein R1 is a 1,2,3,4-tetrahydroquinolyl, 2-oxo-1,2,3,4-tetrahydroquinolyl, 2-oxo-1,2-dihydroquinolyl, indolyl, 2-oxoindolinyl, benzothiazolyl, 2-oxobenzothiazolinyl, 3,4-dihydro-1H-2,1-benzothiazinyl in which the S atom being optionally oxidized, or 3-oxo-2,3-dihydro-4H-1,4-benzoxazinyl, each of which may have one or more substituent(s) selected from lower alkyl, hydroxy(lower)alkyl, lower alkylamino, lower alkanoyl, cyclic lower alkanoyl, lower alkoxy(lower)alkyl, lower alkylamino(lower)alkanoyl, benzyl, benzyloxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl and 4-(2-hydroxyethyl)piperazin-1-yl-carbonylmethyl; R2 is a hydrogen, lower alkenyl, benzyl, carboxy(lower)alkyl or lower alkoxycarbonyl(lower)alkyl; R3 and R4, which may be the same or different, are each hydrogen or lower alkyl or together represent a bond; provided that when R1 is 2-oxo-1,2,3,4-tetrahydroquinolyl which is unsubstituted or substituted by a lower alkyl, then, R4 is a hydrogen or R2 is a lower alkenyl, benzyl, carboxy(lower)alkyl or lower alkoxycarbonyl(lower)alkyl; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.
Triazine derivatives, and pharmaceutical compositions comprising the same
-
, (2008/06/13)
New triazine derivatives represented by the formula: STR1 wherein R1 is hydrogen or halogen; R2 is a hydroxy, protected hydroxy, amino, cyano, mercapto, lower alkylthio, arylthio, sulfamoyl, lower alkylsulfonylamino, lower alkylureido, arylureido, lower alkyl-thioureido, aryl-thioureido, lower alkenoylamino, lower alkoxycarbonylamino, lower alkoxy(thiocarbonyl)thio, or cyclic or acyclic alkanoylamino in which the cyclic and acyclic alkanoylamino group may have a substituent selected from lower alkoxy, aryl, hydroxyaryl and protected hydroxyaryl; and X is O or S; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.
Triazine derivatives, and pharmaceutical compositions comprising the same
-
, (2008/06/13)
New triazine derivatives represented by the formula: STR1 wherein R1 is hydrogen; halogen or hydrazinocarbonyl(lower)alkyl; R2 is hydrazino; azido; halosulfonyl; mono- or di(lower)alkylamino; mono- or di-(lower alkynylamino; pyridylamino; lower alkylideneamino substituted by furyl pyridyl or aryl; mono- or di-(lower)alkylamino substituted by amino, carboxy, hydroxy, ureido, lower alkoxy, lower alkoxycarbonyl, lower alkoxy(lower)alkoxy, aryl, furyl, pyridyl, phthalimido, or succinimido; N-methyl(lower)alkanoylamino; N-containing, 5- or 6-membered heterocyclic group optionally substituted by oxo, lower alkyl and/or lower alkoxycalbonyl; lower alkoxy substituted by hydroxy and lower alkylamino; or a group of the formula STR2 in which R3 is hydrogen; lower alkyl or ar(lower)alkyl; R4 is pyridyl; aryl; styryl; alkynyl; lower alkoxycarbonyl; α-hydroxybenzyl; lower alkanoyl; carboxy; or lower alkyl substituted by halogen, amino, hydroxy, carboxy, lower alkanoyl, lower alkanoyloxy, lower alkoxycarbonyl, morpholino, lower alkoxycarbonylamino, 1-methyl-2-oxo-1,2,3,4-tetrahydroquinolyloxy, mono- or di(lower)alkylamino, piperazinyl being substituted with hydroxy(lower)alkyl or furoyl, or pyrrolidino; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.
