94956-94-2Relevant academic research and scientific papers
Convenient synthesis of pyrrolidines by amphiphilic allylation of imines with 2-methylenepropane-1,3-diols
Kimura, Masanari,Tamaki, Takato,Nakata, Masanori,Tohyama, Katsumi,Tamaru, Yoshinao
supporting information; experimental part, p. 5803 - 5805 (2009/03/11)
(Chemical Equation Presented). A straightforward route: The combination of a palladium catalyst and triethylborane promotes the amphiphilic (nucleophilic-electrophilic) allylation of aldimines, prepared in situ from a wide variety of aromatic and aliphatic aldehydes and amines, with commercially available 2-methylenepropane-1,3-diols to provide pyrrolidines (see scheme).
Reactions between Trimethylenemethane Metal Complexes and the Carbon-Nitrogen Double Bond: Nickel and Palladium catalysed Synthesis of Pyrrolidines
Jones, Michael D.,Kemmitt, Raymond D. W.
, p. 1201 - 1203 (2007/10/02)
The d10 nickel complex 4> catalyses the cycloaddition of trimethylenemethane to the C=N double bond of an imine to afford a high-yield synthesis of 4-methylenepyrrolidines.
