949580-63-6Relevant academic research and scientific papers
Palladium-catalyzed decarboxylative cross-coupling reactions: A route for regioselective functionalization of coumarins
Jafarpour, Farnaz,Zarei, Samaneh,Olia, Mina Barzegar Amiri,Jalalimanesh, Nafiseh,Rahiminejadan, Soraya
supporting information, p. 2957 - 2964 (2013/06/05)
A straightforward, regioselective, and step-economical ligand-free palladium-catalyzed decarboxylative functionalization of coumarin-3-carboxylic acids is devised. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and allows for construction of various biologically important π-electron extended coumarins.
Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents
Matos, Maria J.,Vazquez-Rodriguez, Saleta,Santana, Lourdes,Uriarte, Eugenio,Fuentes-Edfuf, Cristina,Santos, Ysabel,Munoz-Crego, Angeles
, p. 1394 - 1404 (2013/04/23)
A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reported.
