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• 67-52-7 BARBITURIC ACID 
• 2826-30-4 2-(2-nitrobenzylidene)malononitrile 
• 552-89-6 2-nitro-benzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Three-component synthesis of 4H-pyran scaffolds accelerated by a gabapentin-based natural deep eutectic solvent

The development of environmentally benign synthetic protocols has attracted increasing attention in recent organic syntheses. As a part of this concept, our group synthesized a new natural deep eutectic solvent (NADES) by using gabapentin and choline chlo

SCMNPs@Urea/Py-CuCl2: a recyclable catalyst for the synthesis of pyrano[2,3-d]pyrimidinone and pyrano[2,3-d] pyrimidine-2,4,7-trione derivatives

An efficient, simple, and mild strategy for the one-pot multicomponent synthesis of pyrano[2,3-d]pyrimidinone and pyrano[2,3-d]pyrimidine-2,4,7-trione derivatives is described using SCMNPs@Urea/Py-CuCl2 nanoparticles as a reusable heterogeneous magnetic nanocatalyst. The catalyst was characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The SCMNPs@Urea/Py-CuCl2 can be easily collected from the reaction solution by magnetic decantation using a permanent magnetic field and reused in six runs without significant decrease in catalytic activity.

Efficient one-pot synthesis of pyrano[2,3-d]pyrimidinone and pyrido [2,3-d] pyrimidine derivatives by using of Mn-ZIF-8?ZnTiO3 nanocatalyst

Mn-ZIF-8?ZnTiO3 nanocomposite was synthesized by sol-gel method. The morphology and structure of the nanocrystalline Mn-ZIF-8?ZnTiO3 was characterized by SEM, TEM, BET, XRD. The results confirmed the formation of Mn-ZIF-8?ZnTiO3 nanocomposite with particl

Fabrication and characterization of adenine-grafted carbon-modified amorphous ZnO with enhanced catalytic activity

Sustainability has become a countersign and guiding rule for current field of nanocatalysis. Herein, we report a cost-effective, greener, clean, and proficient process for the formation of adenine-grafted carbon-modified amorphous ZnO nanocatalyst (ZnO@AC

A choline chloride-based deep eutectic solvent promoted three-component synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d] pyrimidinone (thione) derivatives

An efficient one-pot method for the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone (thione) derivatives through a three-component reaction between aldehydes, malononitrile and enolizable C–H activated acidic compounds using a new deep eutectic solvent made of choline chloride, urea and thiourea as an environmentally benign catalyst has been reported. The structure of the catalyst was characterized using FT-IR, 1H NMR, and 13C NMR. The present method exhibits some notable advantages such as ease of the preparation and handling of the catalyst, low cost, green reaction conditions, short reaction times, high yields, and simple work-up. Also, the catalyst could be recovered easily and recycled up to four times without significant loss of catalytic activity.

Synthesis of chloro, fluoro, and nitro derivatives of 7-amino-5-aryl-6-cyano-5H-pyrano pyrimidin-2,4-diones using organic catalysts and their antimicrobial and anticancer activities

Chloro, fluoro, and nitro derivatives of 7-amino-5-aryl-6-cyano-5H-pyrano pyrimidin-2,4-diones were produced by reacting malononitrile, barbituric acid, and aromatic aldehydes together with a DABCO catalyst in an aqueous one-pot reaction. This is the firs

Magnetic nanoporous MCM-41 supported ionic liquid/palladium complex: An efficient nanocatalyst with high recoverability

In this study, a novel magnetic mesoporous MCM-41 silica supported ionic liquid/palladium complex (Fe3O4@MCM@IL/Pd) with core-structure was prepared and characterized and its catalytic performance was developed under green conditions

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 as a novel nanostructured Schiff base complex and catalyst for the synthesis of pyrano[2,3-d]pyrimidinedione derivatives

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Zn-2BSMP]Cl2) as a novel nanostructured Schiff base complex was prepared and characterized using several techniques. Nano-[Zn-2BSMP]Cl2 was used as an ef

Comparison of the efficiency of two imidazole-based dicationic ionic liquids as the catalysts in the synthesis of pyran derivatives and Knoevenagel condensations

In the present work, 3,3′-(butane-1,4-diyl)bis(1-methyl-1H-imidazol-3-ium) dichloride ([C4(MIm)2]·2Cl) and 3,3′-(butane-1,4-diyl)bis(1-methyl-1H-imidazol-3-ium) hydrogen sulfate ([C4(MIm)2]·2HSO4) were prepared via adequate, solvent-free methods and characterized using FT-IR, 1H NMR, 13C NMR, and potentiometric titration techniques. These reagents were investigated in the synthesis of 5-arylidene (thio)barbituric acids, 2-arylidene malononitriles, 4H-pyrans, and pyrano[2,3-d] pyrimidineones, and their catalytic activities were compared in the promotion of these reactions. Based on the obtained results, we found that [C4(MIm)2]·2Cl showed more catalytic efficiency where a basic or weak acidic media is needed. In contrast, [C4(MIm)2]·2HSO4 is a powerful catalyst in reactions needing acidic catalysts to enhance the reaction rate. Using these reagents, the products were formed under mild and eco-friendly conditions in excellent yields during short reaction times without needing column chromatography for work-up.