94989-73-8Relevant academic research and scientific papers
Highly enantioselective Rh-catalysed hydrogenation of 1-alkyl vinyl esters using phosphine-phosphoramidite ligands
Konrad, Tina Maria,Schmitz, Pascal,Leitner, Walter,Francio, Giancarlo
supporting information, p. 13299 - 13303 (2013/10/08)
MatPhos, a good mate for hard tasks: The asymmetric hydrogenation of 1-alkyl vinyl esters, thwarted so far by mediocre ee values and low activities, can now be achieved with MatPhos/Rh catalysts with ee values of 96-99 % for a variety of substrates at low catalyst loadings (0.1-1 mol %) and under mild conditions (5-20 bar H2, room temperature). After hydrolysis, the corresponding chiral secondary alkyl alcohols can be obtained in high enantiopurities providing a general and practical route to this important product class. Copyright
Ligand-controlled regio- and stereoselective addition of carboxylic acids onto terminal alkynes catalyzed by carbonylruthenium(0) complexes
Tan, Sze Tat,Fan, Wai Yip
experimental part, p. 4631 - 4635 (2011/02/27)
The addition of carboxylic acids onto terminal alkynes was catalyzed by mononuclear ruthenium(0) complexes to give enol esters in high yields. By using ligands with different electronic properties, product selectivity was achieved. E-enol esters were preferentially produced when tricarbonyl(η4- diene)ruthenium complexes were used; while geminal enol esters were produced when tricarbonylbis(phosphane)ruthenium complexes were used. Product selectivity is a major problem in transition metal-catalyzed hydrocarboxylation reactions. In this paper we report the ability of Ru(CO)3L2 (where L is a 2 e-donor) to catalyze the addition of variouscarboxylic acids onto terminal alkynes. A direct relationship between the regioselectivity of the product and the electronic property of the catalysis metal centre was observed.
