949892-08-4

Usage

Uses

Used in Synthetic Chemistry:
1-Bromo-5-chloro-4-fluoro-2-methoxybenzene is used as a building block for the synthesis of various organic compounds. Its unique structure with halogens and a methoxy group allows for versatile reactions and the creation of a wide range of derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Bromo-5-chloro-4-fluoro-2-methoxybenzene is used as an intermediate in the synthesis of pharmaceutical compounds. Its reactivity and structural features make it a valuable component in the development of new drugs.
Used in Chemical Research:
1-Bromo-5-chloro-4-fluoro-2-methoxybenzene is utilized in chemical research for studying the properties and reactions of halogenated aromatic hydrocarbons. Its unique structure provides insights into the behavior of similar compounds and contributes to the advancement of synthetic chemistry.
Used in Environmental and Health Regulations:
Due to its reactivity and potential environmental and health impacts, 1-Bromo-5-chloro-4-fluoro-2-methoxybenzene is subject to strict regulations in its use and handling. It serves as a case study for understanding the risks associated with halogenated aromatic hydrocarbons and the development of safety protocols.
It is important to handle 1-Bromo-5-chloro-4-fluoro-2-methoxybenzene with care due to its reactivity, and its applications are regulated to minimize potential environmental and health risks.

Upstream product

• 501-29-1 1-chloro-2-fluoro-4-methoxybenzene 
• 74-88-4 methyl iodide 

Downstream Products

• 949892-09-5 5-Chloro-4-fluoro-2-methoxyphenylboronic acid 

Relevant academic research and scientific papers

COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN

The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule approach to disrupting IL-13 signaling. Herein we demonstrate that JAK1 is likely the isoform most important to IL-13 signaling. Structure-based design was then used to improve the JAK1 potency of a series of previously reported JAK2 inhibitors. The ability to impede IL-13 signaling was thereby significantly improved, with the best compounds exhibiting single digit nM IC50’s in cell-based assays dependent upon IL-13 signaling. Appropriate substitution was further found to influence inhibition of a key off-target, LRRK2. Finally, the most potent compounds were found to be metabolically labile, which makes them ideal scaffolds for further development as topical agents for IL-13 mediated diseases of the lungs and skin (for example asthma and atopic dermatitis, respectively).

NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY

An object of the present invention is to synthesize a novel 1,2,3,4-tetrahydroquinoxaline derivative represented by formula (1) and to find a pharmacological action of the derivative. In the formula, the R1 represents a halogen, an alkyl, cycloalkyl, aryl or heterocyclic group, or the like; p represents 0 to 5; R2 represents a halogen, an alkyl, hydroxyl or alkoxy group, or the like; q represents 0 to 2; R3 represents hydrogen, an alkyl, alkenyl, alkylcarbonyl or arylcarbonyl group, or the like; R4 and R5 independently represent hydrogen, a halogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; R6 represents hydrogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; and X represents O or S.