501-29-1

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

InChI:InChI=1/C8H9F/c1-6-3-4-7(2)8(9)5-6/h3-5H,1-2H3

Upstream product

• 458-52-6 2-fluoro-4-(methoxy)aniline 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 865-33-8 potassium methanolate 
• 348-60-7 4-chloro-3-fluorophenol 
• 74-88-4 methyl iodide 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 

Downstream Products

• 1300730-59-9 1-(5-chloro-4-fluoro-2-methoxyphenyl)ethanone 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 

Relevant academic research and scientific papers

EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

Spiro aryl phosphorus oxide or sulfide

The invention discloses a spiro aryl phosphorus oxide or sulfide as ALK inhibitor, and in particular discloses a compound shown in a formula (I) as an ALK inhibitor or a pharmaceutically acceptable salt thereof.

IMIDAZOLE DERIVATIVES AS IDO INHIBITORS

Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen