501-29-1

Basic information

• Product Name: 4-CHLORO-3-FLUOROANISOLE
• Synonyms: 4-Chloro-3-fluoroanisole 98%;4-Chloro-3-fluoroanisole98%;3-Fluoro-4-chloroanisole;4-Chloro-3-fluoroanisole,97%;chloro-2-fluoro-4-methoxybenzene;Benzene, 1-chloro-2-fluoro-4-Methoxy-;1-CHLORO-2-FLUORO-4-METHOXYBENZENE;4-CHLORO-3-FLUOROANISOLE
• CAS NO: 501-29-1
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• Product Categories: Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Fluorine Compounds
• Mol File: 501-29-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 200-204°C
• Flash Point: 60.8±21.8℃
• Appearance: Clear colourless liquid
• Density: 1.26
• Vapor Pressure: 6.332mmHg at 25°C
• Refractive Index: 1.516-1.518
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CHLORO-3-FLUOROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROANISOLE(501-29-1)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROANISOLE(501-29-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• RIDADR: 1993
• Hazardous Substances Data: 501-29-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

InChI:InChI=1/C8H9F/c1-6-3-4-7(2)8(9)5-6/h3-5H,1-2H3

Upstream product

• 458-52-6 2-fluoro-4-(methoxy)aniline 
• 348-60-7 4-chloro-3-fluorophenol 
• 74-88-4 methyl iodide 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 865-33-8 potassium methanolate 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 

Downstream Products

• 398456-81-0 3-chloro-2-fluoro-6-methoxybenzaldehyde 
• 1300730-59-9 1-(5-chloro-4-fluoro-2-methoxyphenyl)ethanone 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 

Relevant articles and documents

EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

IMIDAZOLE DERIVATIVES AS IDO INHIBITORS

Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.