949894-90-0Relevant academic research and scientific papers
CuAAC macrocyclization: High intramolecular selectivity through the use of copper-tris(triazole) ligand complexes
Chouhan, Gagan,James, Keith
, p. 2754 - 2757 (2011/06/26)
A range of multivalent heteroaryl ligands, copper sources, and solvent systems have been investigated for use in CuAAC-mediated macrocyclization reactions. These studies have revealed the key factors governing selectivity for macrocyclization versus dimerization and identified a simple but specific set of reaction conditions capable of efficiently generating a diverse series of drug-like macrocycles at modest dilution in up to 95% yield.
