1044548-57-3

Upstream product

• 949894-57-9 (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl) propanoate 
• 1080-06-4 L-Tyr-OMe 
• 106-96-7 propargyl bromide 
• 3978-80-1 Boc-Tyr-OH 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 

Downstream Products

• 1004751-63-6 C₅₃H₅₈N₈O₇ 
• 1301627-69-9 C₁₆H₂₀N₂O₄*ClH 
• 1301627-70-2 C₂₀H₂₅N₅O₅ 
• 1301627-80-4 C₃₀H₃₇N₃O₇ 
• 1301627-81-5 C₃₁H₃₈N₆O₆ 
• 1301627-58-6 C₃₁H₃₈N₆O₆ 
• 949894-90-0 C₂₁H₂₈N₂O₆ 
• 1359969-17-7 (S)-2-amino-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-1-ol 
• 1359969-76-8 benzyl ((S)-5-azido-1-(((S)-1-(((S)-1-hydroxy-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate 
• 1359969-79-1 benzyl ((S)-6-azido-1-(((S)-1-(((S)-1-hydroxy-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)carbamate 
• 1359969-83-7 benzyl ((S)-6-azido-1-(((S)-1-(((S)-1-hydroxy-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)carbamate 
• 1359969-86-0 benzyl N-[(11S,14S,17S)-17-(hydroxymethyl)-14-(2-methylpropyl)-12,15-dioxo-2-oxa-5,6,7,13,16-pentaazatricyclo[17.2.2.1(4,7)]tetracosa-1⁽²¹⁾,4⁽²⁴⁾,5,19,22-pentaen-11-yl]carbamate 
• 1359969-89-3 benzyl N-[(12S,15S,18S)-18-(hydroxymethyl)-15-(2-methylpropyl)-13,16-dioxo-2-oxa-5,6,7,14,17-pentaazatricyclo[18.2.2.1(4,7)]pentacosa-1⁽²²⁾,4⁽²⁵⁾,5,20,23-pentaen-12-yl]carbamate 
• 1359969-92-8 benzyl N-[(12S,15S,18S)-15-benzyl-18-(hydroxymethyl)-13,16-dioxo-2-oxa-5,6,7,14,17-pentaazatricyclo[18.2.2.1(4,7)]pentacosa-1⁽²²⁾,4⁽²⁵⁾,5,20,23-pentaen-12-yl]carbamate 

Relevant academic research and scientific papers

Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues

We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.

MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

New β-strand templates constrained by Huisgen cycloaddition

New peptidic templates constrained into a β-strand geometry by linking acetylene and azide containing P1 and P3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a β-strand are shown to be potent inhibitors of the protease calpain. The β-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.

CuAAC macrocyclization: High intramolecular selectivity through the use of copper-tris(triazole) ligand complexes

A range of multivalent heteroaryl ligands, copper sources, and solvent systems have been investigated for use in CuAAC-mediated macrocyclization reactions. These studies have revealed the key factors governing selectivity for macrocyclization versus dimerization and identified a simple but specific set of reaction conditions capable of efficiently generating a diverse series of drug-like macrocycles at modest dilution in up to 95% yield.

Non-enzymatic covalent protein labeling using a reactive tag

We describe herein a new method for covalent labeling of proteins using a complementary recognition pair of peptide tag and synthetic molecular probe. The rapid and specific covalent labeling of a tag-fused protein was achieved by the reaction on the tag