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Usage

Uses

Used in Pharmaceutical Industry:
(1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol is used as a building block in the synthesis of biologically active molecules for pharmaceutical applications. Its unique structure, including the trifluoromethyl group, may enhance the biological activity and metabolic stability of the resulting compounds, making it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol serves as a key intermediate in the synthesis of agrochemicals with potential pesticidal or herbicidal properties. The presence of the trifluoromethyl group could improve the effectiveness and persistence of these agrochemicals in the environment.
Further Research:
While (1-Methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-methanol shows promise in both pharmaceutical and agrochemical applications, further research is necessary to fully explore its potential uses and properties. This includes understanding its interactions with biological systems, optimizing its synthesis for large-scale production, and evaluating its safety and efficacy in various applications.

Upstream product

• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 
• 60-34-4 methylhydrazine 

Downstream Products

• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of functionalized fluoroalkyl pyrimidines and pyrazoles from fluoroalkyl enones

The synthesis of a series of polyfluoromethyl-substituted pyrimidines and pyrazoles bearing potential for further functionalization of the hydroxymethyl group prepared from the fluoroalkyl-containing enones with isothioureas, amidine and hydrazines, is reported. We investigated the deoxyfluorination of hydroxymethyl group in polyfluoromethyl containing pyrazoles and obtained di- and trifluoromethyl pyrazoles with an additional monofluoromethyl group.

Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

A facile synthetic route toward either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale. The elaborated approach extends the scope of fluoroalkyl substituents for introduction into the heterocyclic moiety, and uses convenient transformations of the side chain for incorporation of fluoroalkyl-substituted azoles into the structures of biologically active molecules. The utility of the obtained building blocks for isosteric replacement of alkyl-substituted isoxazole and pyrazole was shown by the synthesis of fluorinated Isocarboxazid and Mepiprazole analogues.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50 = 35-145 nM) inhibitor against multiple primary isolates of diverse measles vir