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ReModelin is a 2-thiazolylhydrazone derivative that acts as an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. It is effective in improving nuclear architecture, chromatin organization, and survival of cells lacking lamin A and cells from patients with progeria, a genetic disorder characterized by premature aging.
Used in Pharmaceutical Industry:
ReModelin is used as a therapeutic agent for the treatment of progeria, specifically targeting the mutation in lamin A that results in misshapen cell nuclei and DNA damage. By inhibiting NAT10, ReModelin improves nuclear morphology and enhances the survival of affected cells.
Used in Antifungal Applications:
ReModelin is used as an antifungal agent, exhibiting cytotoxic effects against some species of the fungus Candida. This makes it a potential candidate for the development of antifungal treatments.

949912-58-7

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949912-58-7 Usage

References

1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

Check Digit Verification of cas no

The CAS Registry Mumber 949912-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,9,9,1 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 949912-58:
(8*9)+(7*4)+(6*9)+(5*9)+(4*1)+(3*2)+(2*5)+(1*8)=227
227 % 10 = 7
So 949912-58-7 is a valid CAS Registry Number.

949912-58-7 Well-known Company Product Price

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  • Sigma

  • (SML1112)  Remodelin hydrobromide  ≥98% (HPLC)

  • 949912-58-7

  • SML1112-5MG

  • 1,107.99CNY

  • Detail
  • Sigma

  • (SML1112)  Remodelin hydrobromide  ≥98% (HPLC)

  • 949912-58-7

  • SML1112-25MG

  • 4,469.40CNY

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949912-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

1.2 Other means of identification

Product number -
Other names Remodelin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:949912-58-7 SDS

949912-58-7Downstream Products

949912-58-7Relevant academic research and scientific papers

Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.

Chimenti, Franco,Bizzarri, Bruna,Maccioni, Elias,Secci, Daniela,Bolasco, Adriana,Fioravanti, Rossella,Chimenti, Paola,Granese, Arianna,Carradori, Simone,Rivanera, Daniela,Lilli, Daniela,Zicari, Alessandra,Distinto, Simona

, p. 4635 - 4640 (2008/12/20)

In this paper, we report on the synthesis of a novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity. All synthesized compounds were screened for their in vitro activities agains

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