949920-92-7Relevant articles and documents
Synthesis and biological activity of novel N-substituted 4-amino-6,7,8-trimethoxyquinazoline compounds
Liu, Gang,Liu, Chunping,Sun, Lin,Qu, Rongjun,Chen, Hou,Ji, Chunnuan
, p. 1290 - 1300 (2007)
A series of N-substituted 4-amino-6,7,8-trimethoxyquinazoline derivatives has been synthesized from 4-chloro-6,7,8-trimethoxyquinazoline and aryl (or benzyl) amines using 2-propanol as a solvent. The starting material 4-chloro-6,7,8-trimethoxyquinazoline has been synthesized from natural gallic acid by a novel route. Their structures have been verified by elemental analysis and IR, 1H, and 13C NMR spectroscopy. The title compounds have been evaluated for their in vitro antiproliferative activities against some cancer cells by the MTT method. Unfortunately, most of the compounds tested have exhibited a weaker anticancer activity than the reference standard drug PD153035.
Microwave assisted synthesis of novel 6,7,8-trimethoxy N-substituted-4- aminoquinazoline compounds
Liu, Gang,Sun, Lin,Liu, Chunping,Ji, Chunnuan,Wen, Quanwu,Ma, Songmei
, p. 759 - 764 (2008/09/21)
(Chemical Equation Presented) A fast, efficient and convenient reaction of 6,7,8-trimethoxy-4-chloroquinazoline and aryl (or benzyl) amines was achieved under microwave irradiation in isopropyl alcohol, providing a simple method for synthesis of novel 6,7,8-trimethoxy N-substituted-4-aminoquinazoline compounds in good yield in short time. The title compounds were evaluated for their in vitro anti-proliferative activities against PC3 cell by MTT method.
