949922-27-4

Basic information

• Product Name: 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone
• Synonyms: 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone
• CAS NO: 949922-27-4
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 949922-27-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone(949922-27-4)
• EPA Substance Registry System: 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone(949922-27-4)

Safety Data

• Hazardous Substances Data: 949922-27-4(Hazardous Substances Data)

Usage

General Description

1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone is a chemical compound with the molecular formula C11H13NO. It is a ketone derivative with a unique structure that includes a tetrahydroisoquinoline ring. 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone is often used as a building block in organic synthesis for the creation of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a reagent in chemical reactions to introduce the tetrahydroisoquinoline group into other molecules. Additionally, 1-(1,2,3,4-Tetrahydroisoquinolin-6-yl)ethanone has potential biological and pharmacological properties, making it a target for research in the development of new drugs and therapeutic agents.

Upstream product

• 158984-84-0 6-trifluoromethanesulfonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 158984-83-9 N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 111-34-2 -butyl vinyl ether 
• 371222-34-3 tert-butyl 6-(Methoxy(methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 170097-67-3 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1008518-35-1 tert-butyl 6-acetyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Downstream Products

• 1254062-81-1 1-[2-(4-cyclopropylmethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]ethanone 

Relevant articles and documents

GPR103 antagonists demonstrating anorexigenic activity in vivo: Design and development of pyrrolo[2,3- c ]pyridines that mimic the c-terminal arg-phe motif of QRFP26

GPR103, a G-protein coupled receptor, has been reported to have orexigenic properties through activation by the endogenous neuropeptide ligands QRFP26 and QRFP43. Recognizing that central administration of QRFP26 and QRFP43 increases high fat food intake in rats, we decided to investigate if antagonists of GPR103 could play a role in managing feeding behaviors. Here we present the development of a new series of pyrrolo[2,3-c]pyridines as GPR103 small molecule antagonists with GPR103 affinity, drug metabolism and pharmacokinetics and safety parameters suitable for drug development. In a preclinical obesity model measuring food intake, the anorexigenic effect of a pyrrolo[2,3-c]pyridine GPR103 antagonist was demonstrated. In addition, the dynamic 3D solution structure of the C-terminal heptapeptide of the endogenous agonist QRFP26 (20-26) was determined using NMR. The synthetic pyrrolo[2,3-c] pyridine antagonists were compared to this experimental structure, which displayed a possible overlay of pharmacophore features supportive for further design of GPR103 antagonists.

PIPERAZINYL OXOALKYL TETRAHYDROISOQUINOLINES AND RELATED ANALOGUES

Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are parti