158984-83-9

Basic information

• Product Name: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
• Synonyms: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;6-HYDROXY-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate;N-BOC-6-HYDROXY-3,4-DIHYDRO-ISOQUINOLINE;6-hydroxy-2-N-Boc-3,4-dihydroisoquinoline;tert-Butyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;tert-Butyl 6-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate;2-N-Boc-6-Hydroxy-3,4-dihydroisoquinoline
• CAS NO: 158984-83-9
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol File: 158984-83-9.mol
• Article Data: 43

Chemical Properties

• Melting Point: 110-111.5 °C
• Boiling Point: 391.376 °C at 760 mmHg
• Flash Point: 190.497 °C
• Appearance: /
• Density: 1.171 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• PKA: 9.79±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(158984-83-9)
• EPA Substance Registry System: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(158984-83-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 158984-83-9(Hazardous Substances Data)

Usage

Uses

tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate is a chemical reagent used in the synthesis of androgen receptor modulators.

InChI:InChI=1/C14H19NO3/c1-14(2,3)18-13(17)15-7-6-10-8-12(16)5-4-11(10)9-15/h4-5,8,16H,6-7,9H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 63905-73-7 6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 188576-49-0 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester 
• 22246-12-4 6-methoxy-1,2,3,4-tetrahydro-1-oxoisoquinoline 
• 591-31-1 3-methoxy-benzaldehyde 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 57196-62-0 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 942150-85-8 bis(6-methoxy-N-1,2,3,4-tetrahydroisoquinolinyl)methane 
• 110-89-4 piperidine 
• 59839-23-5 6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 14446-24-3 6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 7651-82-3 isoquinolin-6-ol 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 

Downstream Products

• 158984-84-0 6-trifluoromethanesulfonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1046816-76-5 tert-butyl 6-(3-(4-(5-ethylpyrimidin-2-yl)phenyl)propoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 893566-72-8 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 164148-88-3 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1429253-97-3 C₂₈H₂₆N₄O₂ 
• 1429254-04-5 C₂₄H₂₅N₃O₃ 
• 630407-52-2 6-ethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 252061-94-2 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline 

Relevant articles and documents

An improved procedure for the cyanation of aryl triflates: A convenient synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline

A short synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline is presented. The key step is an improved method of aryl triflate cyanation employing zinc(II)cyanide as the cyanide source.

MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION

Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated

Azacyclic derivative as well as preparation method and medical use thereof

The invention relates to an azacyclic derivative as well as a preparation method and medical use thereof and particularly relates to an azacyclic derivative represented by a general formula (I) (shownin the description), a preparation method thereof, a pharmaceutical composition containing the derivative and use of the derivative as an SMO antagonist, particularly in the treatment of diseases such as cancer related to Hedgehog signal channels. The definitions of groups in the general formula (I) are same as the definitions in the description.