949928-09-0Relevant articles and documents
Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H3 receptor antagonists
Cole, Derek C.,Gross, Jonathan L.,Comery, Thomas A.,Aschmies, Suzan,Hirst, Warren D.,Kelley, Cody,Kim, Ji-In,Kubek, Katie,Ning, Xiaoping,Platt, Brian J.,Robichaud, Albert J.,Solvibile, William R.,Stock, Joseph R.,Tawa, Gregory,Williams, Marla J.,Ellingboe, John W.
, p. 1237 - 1240 (2010)
Using a focused screen of biogenic amine compounds we identified a novel series of H3R antagonists. A preliminary SAR study led to reduction of MW while increasing binding affinity and potency. Optimization of the physical properties of the ser
N-substituted-azacyclylamines as histamine-3 antagonists
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Page/Page column 12, (2010/11/28)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.