949928-08-9

Basic information

• Product Name: 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester
• Synonyms: 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester
• CAS NO: 949928-08-9
• Molecular Weight: 342.397
• Mol File: 949928-08-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester(949928-08-9)
• EPA Substance Registry System: 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester(949928-08-9)

Safety Data

• Hazardous Substances Data: 949928-08-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 716-79-0 2-phenyl-1H-benzoimidazole 

Downstream Products

• 949928-09-0 4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoic acid 

Relevant articles and documents

1,2-Disubstituted Benzimidazoles by the Iron Catalyzed Cross-Dehydrogenative Coupling of Isomeric o-Phenylenediamine Substrates

Benzimidazoles are common in nature, medicines, and materials. Numerous strategies for preparing 2-arylbenzimidazoles exist. In this work, 1,2-disubstituted benzimidazoles were prepared from various mono- and disubstituted ortho-phenylenediamines (OPD) by iron-catalyzed oxidative coupling. Specifically, O2 and FeCl3·6H2O catalyzed the cross-dehydrogenative coupling and aromatization of diarylmethyl and dialkyl benzimidazole precursors. N,N′-Disubstituted-OPD substrates were significantly more reactive than their N,N-disubstituted isomers, which appears to be relative to their propensity for complexation and charge transfer with Fe3+. The reaction also converted N-monosubstituted OPD substrates to 2-substituted benzimidazoles; however, electron-poor substrates produce 1,2-disubstituted benzimidazoles by intermolecular imino-transfer. Kinetic, reagent, and spectroscopic (UV-vis and EPR) studies suggest a mechanism involving metal-substrate complexation, charge transfer, and aerobic turnover, involving high-valent Fe(IV) intermediates. Overall, comparative strategies for the relatively sustainable and efficient synthesis of 1,2-disubstituted benzimidazoles are demonstrated.

N-substituted-azacyclylamines as histamine-3 antagonists

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.